Development of Multifunctional Envelope Type Artificial Viral like Gene Delivery System
نویسندگان
چکیده
منابع مشابه
[Development of multifunctional envelope type artificial viral-like gene delivery system].
This review introduces a new concept "Programmed Packaging" to develop a non-viral gene delivery system. Based on this concept, multifunctional envelope type nano devices (MEND) were developed for in vitro, in situ and in vivo conditions. A quantitative study to identify a rate limiting step in intracellular trafficking was also shown between viral and non-viral vectors, which indicated an impo...
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For efficient gene delivery to the nucleus, nonviral vectors need to overcome several barriers such as the plasma membrane, endosomal membrane, and nuclear membrane. To overcome these obstacles, it is necessary to equip the delivery system with various functional devices. However, it is difficult to package all such functional devices into a single system to exert each of their functions at the...
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Artificial nucleic acids have recently been widely used with their properties optimized for various technologies such as the inhibition of gene expression (antisense/antigene strategies, RNA interference) and genetic diagnosis (single nucleotide polymorphism (SNP), damaged nucleobase). For practical application of nucleic acid therapeutics, establishment of an effective delivery system for olig...
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The importance of gene therapy strategies for the treatment of malignancies is highlighted by the fact that there are (at the time of writing) 823 cancer gene therapy clinical trials world‐ wide that are actively, or have yet to begin recruiting patients (www.clinicaltrials.gov ac‐ cessed November 2012). The potential of the delivery of genetic material for therapeutic purposes has long been re...
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Recommended Citation Wongrakpanich, Amaraporn. "The development of cationic polymers for non-viral gene delivery system." PhD (Doctor of Philosophy) thesis, ii To my parents iii ACKNOWLEDGMENTS My deep gratitude goes first to my advisor, Dr. Aliasger K. Salem for giving me the opportunity to do research in his lab and teaching me how to design and carryout experiments independently. His ability...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 2007
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi.127.1655